SREBF1 and obesity due to melanocortin 4 receptor deficiency: Other anti-obesity mechanism reported for A. vera is the regulation of expression levels of hepatic genes encoding to lipogenic enzymes (ACC, FAS), and transcriptor factor SREBP-1, which decreased significantly by the administration of aloe sterols; and to the increased of hepatic β-oxidation enzymes ACO, CPT1, PPARα (Misawa et al., 2012[94]).