Different anti-obesity acting mechanisms have been reported for C. sinensis, including inhibition of pancreatic lipase (Grove et al., 2012[54]; Yuda et al., 2012[155]), appetite-repression activity (Moon et al., 2007[97]; Wolfram et al., 2006[148]), adipogenesis down-regulation (Lu et al., 2012[85]), thermogenesis (Hursel et al., 2011[65]), lipid metabolism (Axling et al., 2012[6]; Lu et al., 2012[85]), among others. Here, PNLIP is linked to obesity due to melanocortin 4 receptor deficiency.