Several anti-obesity acting mechanisms were reported for H. sabdariffa included the down-regulation of genes involved in lipid metabolism such as free fatty acid synthase (FAS) and Sterol Regulatory Element-Binding Proteins (SREBP1c) (Gamboa-Gómez et al., 2014[47]). This evidence concerns the gene SREBF1 and obesity due to melanocortin 4 receptor deficiency.