MAT2A and hepatocellular carcinoma: Moreover, in human hepatoma cell lines, hypoxia induces genomic DNA demethylation through the direct activation of Methionine adenosyltransferase 2A (MAT2A) that maintains the S-adenosylmethionine (SAM)/S-adenosylhomocysteine (SAH) ratio, a critical marker of genomic methylation status [73].