To classify cancer samples validly, eight significant genes (MYBL1, LMO2, BCL6, MME, IRF4, NFKBIZ, PDE4B, and SLA) were selected in 414 patients treated with CHOP/R‐CHOP chemotherapy from Gene Expression Omnibus (GEO) data sets. The gene discussed is NFKBIZ; the disease is cancer.