We used machining learning method to screen and obtain eight specific markers, including MYBL1, LMO2, BCL6, MME, IRF4, NFKBIZ, PDE4B, and SLA, to stratify DLBCL patients through the significantly different expression among GCB, ABC, and unclassified types. The gene discussed is PDE4B; the disease is diffuse large B-cell lymphoma.