Combined with our algorithm analysis, IkB‐ζ encoded by ABC DLBCL‐specific gene NFKBIZ, was essential for the expression of a specific set of NF‐kB target genes (CARD11, CD79A, CD79B, and MYD88), which were essential for ABC‐DLBCL patients' poor survival 43, 44, 45, 46. Here, CARD11 is linked to diffuse large B-cell lymphoma.