In autoimmune thyroiditis presenting with mood disorders (Table 3), thyroid hormone substitution has been used in case of hypothyroidism (Schmidt et al. 1990; Mahmud et al. 2003; Stowell and Barnhill 2005; Tor et al. 2007; Liu et al. 2011; Lin et al. 2013) or antithyroid drugs in case of hyperthyroidism (Bokhari et al. 1998; Müssig et al. 2005). This evidence concerns the gene TG and hypothyroidism.