Aberration of lncRNA transcription including that of lncRNA-p21, KCNQ1OT1, colorectal cancer associated transcript 1 long isoform (CCAT1-L), HOTAIR, E2F4 antisense transcript and metastasis associated lung adenocarcinoma transcript 1 (MALAT1) has been observed in colorectal cancer that harbors alteration of Wnt/β-catenin signaling pathways9, 15, 21, 22, 23, 24. The gene discussed is E2F4; the disease is colorectal cancer.