PHLDA2 and colorectal cancer: Thus, these results indicated that a decrease in β-catenin activity can cause at least dysregulation of the expression of KCNQ1OT1-targeted genes through contraction of KCNQ1OT1 lncRNA-coated territory from SLC22A18 to PHLDA2 locus, suggesting that fluctuation in KCNQ1OT1 lncRNA by the accumulation of nuclear β-catenin may play a role as an important step in colorectal cancer development.