MiR-132 has been reported as a tumor suppressor in a series of cancers.9,12–15 Zheng et al. showed that miR-132 inhibits CRC invasion and metastasis via directly targeting ZEB2 using 62 CRC samples.15 Our study extended their findings with a possible target ANO1 using a large scale of CRC samples (n = 163) as well as their metastatic lesions to liver (n = 24). This evidence concerns the gene ANO1 and cancer.