MKI67 and neoplasm: In addition, there was a substantial decrease in tumor cell proliferation (Ki-67-positive cells, from 52 ± 7.7 to 2.6 ± 1.2%) as well as a clear increase in apoptosis (TUNEL- positive cells, from 2.7 ± 0.7 to 16.3 ± 2.4%) compared with tumors of the group treated with vehicle.