Intriguingly, the protective G-allele of rs662463 (associated with higher CDKN2B expression) is part of a ChIP-seq-validated TFBS for CEBPB (CCAAT/enhancer-binding protein β), a TF important for haematopoietic differentiation that is mutated in some BCP-ALL patients16, and substitution by the risk A-allele (associated with lower CDKN2B expression) disrupts this binding motif (Fig. 3b)26, 27, 28. Here, OPN1SW is linked to acute lymphoblastic leukemia.