As stable translation is dependent on the presence of a 3′-untranslated region35, these data may suggest increasing dosage of the rs3731217 G-allele is associated with protection against BCP-ALL by promoting transcript isoforms of CDKN2A containing exon 3, resulting in higher protein levels of the tumour suppressors encoded by this gene. Here, CDKN2A is linked to acute lymphoblastic leukemia.