However, two previous studies have reported haplotype in COL11A2 at 6p21.3 associated with nonsnyndromic cleft [33, 34] while Melkoniemi et al., [35] found it was associated with Pierre-Robin sequence, cleft palate, micrognathia and it may possibly be predisposed to nonsyndromic conditions. The gene discussed is COL11A2; the disease is Micrognathia.