Suggestive linkage of LOD score in family 99 and HLOD ≥1 in total family for 3q13.3-13.33 chromosomal region brought to the interest of this study, with the findings of Poliovirus Receptor-Related 3 (PVRL3) gene related to orofacial cleft. The gene discussed is NECTIN3; the disease is orofacial cleft.