This is, to the best of our knowledge, the first case-control study estimating the effect of MDM4 SNP34091 on risk for endometrial cancer and, although a small study found an increased risk for relapse and early onset of ovarian cancer among individuals carrying the SNP34091A allele [20], no study has evaluated MDM4 SNP34091 status as a potential risk factor with respect to ovarian cancer. Here, MDM4 is linked to endometrial cancer.