In this study, for the first time, we investigated the expression of CD80, CD86, PD1, PD-L1, Tim-3, CD40 and TIGIT on neutrophils from patients with SLE, and showed that the frequency of PD-L1-expressing neutrophils was significantly increased in patients with SLE compared with healthy individuals. Here, HAVCR2 is linked to systemic lupus erythematosus.