Additionally, we made the observation that the frequency of PD-L1-expressing neutrophils was inversely associated with red blood cell (RBC) count (r2 = 0.14, P = 0.0011) (Fig. 5a), hemoglobin (HGB) level (r2 = 0.08, P = 0.0153) (Fig. 5b) and hematocrit (HCT) (r2 = 0.16, P = 0.0004) (Fig. 5c), indicated that the frequency of PD-L1-expressing neutrophils was correlated with erythrocytopenia and anemia. The gene discussed is CD274; the disease is anemia.