ITGA7 and cardiac hypertrophy: MYH7B expression is up-regulated during induced cardiac hypertrophy in mice [48], and a loss-of-function mutation in the MYH7B gene has been proposed to underlie congenital myopathy with left ventricular non-compact cardiomyopathy when combined with a mutation in the integrin alpha 7 (ITGA7) gene in human patients [66].