Indeed, in Japanese COPD patients, emphysema is the most common phenotype; the ED and the mixed phenotypes represent the majority of cases [24], Similarly, most of the patients in this study were non-obese (Table 1), but the EAT correlated positively with the √Aaw at Pi10, which suggests epicardial fat accumulation and airway remodeling may share a pathogenetic mechanism. This evidence concerns the gene SERPINB10 and pulmonary emphysema.