Although inhibition of PI3k/Akt and MAPK signaling pathways by EGCG has been reported involved in the anti-inflammatory mechanism in ameliorating crescentic glomerulonephritis [56], the NLRs, which are cystolic PRRs, and NLR-activated inflammasome, typically NLRP3, aroused our interest. Here, AKT1 is linked to crescentic glomerulonephritis.