HMOX1 and cervical squamous intraepithelial neoplasia: Blocking HO-1 activity by ZnPP almost completely abrogated the renal protective effect of EGCG on CIN; it reversed the beneficial effect of EGCG on serum Cr, BUN (Fig 3D and 3E), and kidney MDA, SOD (Fig 3A and 3B), indicating that these renal protective and antioxidant effects of EGCG may via HO-1.