IARS1 and Insulin resistance: Impaired Akt signalling and decreased IRS expression in the livers have been shown to be the underlying causes of insulin resistance in ob/ob and lipodystrophic mice.11, 12 Our earlier studies had shown that FAIM expression was essential for the activation of Akt in thymocytes14 and myeloma cells.15 Therefore, it is conceivable that FAIM deficiency may lead to impaired Akt activation and defective insulin signalling in insulin target tissues.