Research has indicated that overexpression of HDAC7 and its interaction with MEF2 family genes in ALL largely inhibits transcription in lymphoid cells, causing failure of normal differentiation in lymphoid lineage.39,40 Some studies have shown the relationship between overexpression of HDAC7 and t(12; 21) ETV6-RUNX1 in ALL. The gene discussed is ETV6; the disease is acute lymphoblastic leukemia.