TP53 and neoplasm: It can regulate the acetylation of genes in several transcription factors, including P53, Ku70, FOXOs, E2F1, NF-KB, C-Myc and N-Myc, which may lead to proliferation of malignant cells.44,45,46 The precise role of SIRT-1 in malignancies depends on tumor type and P53 involvement.