In addition, ccRCC driver genes, VHL, PBRM1, TCEB1, BAP1 and SETD2, are all located in the low scoring 1-Kb windows, their average CSM scores are 21.436, 20.7088, 25.043, 20.7625 and 20.3447 respectively, which are less than the average (25.0582) in ccRCC. The gene discussed is PBRM1; the disease is nonpapillary renal cell carcinoma.