Given that the expression profiles and functional characteristics of HAND2 overlap at least partially with those of HAND1 (Srivastava et al. 1995, 1997; McFadden et al. 2005; Vincentz et al. 2011), screening HAND2 as a prime candidate gene in CHD patients is justifiable (Shen et al. 2010; Töpf et al. 2014). Here, HAND2 is linked to coronary artery disorder.