LOX and posterior cortical atrophy: In arachidonic acid (AA) metabolism, genes ALOX15B (arachidonate 15-lipoxygenase, type B) and PTGES3 (prostaglandin E synthase 3), involved in COX (cyclooxygenase) and LOX (lipoxygenase) pathways showed significantly increased expression in PCa (supplementary Fig. S4), probably suggesting an enhanced synthesis of downstream bioactive metabolites.