In arachidonic acid (AA) metabolism, genes ALOX15B (arachidonate 15-lipoxygenase, type B) and PTGES3 (prostaglandin E synthase 3), involved in COX (cyclooxygenase) and LOX (lipoxygenase) pathways showed significantly increased expression in PCa (supplementary Fig. S4), probably suggesting an enhanced synthesis of downstream bioactive metabolites. The gene discussed is ALOX15B; the disease is posterior cortical atrophy.