In arachidonic acid (AA) metabolism, genes ALOX15B (arachidonate 15-lipoxygenase, type B) and PTGES3 (prostaglandin E synthase 3), involved in COX (cyclooxygenase) and LOX (lipoxygenase) pathways showed significantly increased expression in PCa (supplementary Fig. S4), probably suggesting an enhanced synthesis of downstream bioactive metabolites. Here, PTGES3 is linked to posterior cortical atrophy.