PLA2G2A and posterior cortical atrophy: Since PUFA-acyl chains are predominantly located at the sn-2 position28, this activated remodeling characterized by coordinated actions of PLA2s and lysophospholipid acyltransferase (LPLATs) (i.e. enhanced hydrolysis by PLA2s and selective reacylation by LPLATs), contributed to increased MUFA% and reduced PUFA% in PLs in PCa (Fig. 1E,F and supplementary Table S4).