On the other hand, the biomarkers of chondrosarcoma, such as CEA, EMA, pan-K, and S-100 [26–28], showed a slight positive reaction in the spindle cells of perichondral fibrous tissue (Fig. 4G–J) but an almost negative reaction in the tumor cells of osteochondroma (Fig. 4L–N). This evidence concerns the gene CEACAM5 and chondrosarcoma.