On IHC staining of oncogenic protein expression, the bizarre chondrocytes of BPOP were strongly positive for β-catenin, BCL2, and pAKT and consistently positive for p53 and survivin (Fig. 4B–F), while some tumor cells of osteochondroma were positive for β-catenin and 14-3-3 and weakly positive for p53, pAKT, BCL2, and survivin (Fig. 5M–R). Here, TP53 is linked to Osteochondroma.