The oncogenic protein expression of perichondral spindle cells and marrow osteoblasts/fibroblasts of BPOP was strongly positive for p53, β-catenin, BCL2, pAKT, and survivin, while osteochondroma was weakly positive for β-catenin and 14-3-3 and rarely positive for p53, BCL2, pAKT, and survivin. Here, TP53 is linked to Osteochondroma.