In contrast, when the IISHMS were applied, abdominal obesity was mainly related to being female (vs. male), previous smoker (vs. current smokers), Caucasian (vs. Asian), from the USA (vs. Asia or other areas), antihypertensive drug intake (four antihypertensive drugs vs. zero antihypertensive drugs), insulin plus OAD treatment (vs. OADs only), higher levels of TG and lower levels of HDL-C. This evidence concerns the gene INS and Abdominal obesity.