RAC1 and laryngotracheoesophageal cleft: As shown in Fig 5A and 5B, Table 4 and Table 5, inhibition of Rac1 impeded directional movement in dcEF of both BC and LC cells, however the effect was much stronger for lamellipodia forming cells (cos γ = 0.42 ± 0.07 for BC and 0.25 ± 0.07 for LC) and the difference was statistically significant (p<0.05).