GJC3 and carcinoma: N-Terminal sequences are recognized to be crucial for function in many connexins [88,89] and there are 4 single nucleotide polymorphisms (SNPs) observed in this discovered region of GJC3 (Fig 11: M1V (C/T rs192406037), F5V (A/T rs187126645), P19H (G/T rs201016616), and R22H (C/T rs200074250)) and three somatic mutations p.R8Q (COSM3267470, c.23G/A; carcinoma, upper aerodigestive tract), p.L25I (COSM1093913, c.73C/I; carcinoma, endometrium) and p.V27M (COSM5184309, c.79G/A; carcinoma, large intestine).