Similar findings were reported for multiple myeloma cells where IFN-β induced apoptosis by TRAIL expression, which in turn signaled via an autocrine/ paracrine feedback loop through its receptors DR5 (or DR4) concomitant with recruitment of caspase-8 to the plasma membrane and subsequent cleavage [54]. The gene discussed is TNFRSF10A; the disease is AL amyloidosis.