For that three candidate antigens, Spastin (SPAST), speckle-type POZ protein (SPOP), and syntaxin 18 (STX18), were selected according to the following criteria: (i) autoantibodies are amongst the top differentially abundant inflammation–associated ones according to p-values and fold change (S2 Table); (ii) antibodies for IHC are commercially available and the corresponding antigen levels are sufficient for immunohistological detection according to the Human Protein Atlas (www.proteinatlas.org); (iii) associations with different cancer types had been reported (Table 3). The gene discussed is SPOP; the disease is cancer.