Bone marrow (BM) from these mice was harvested and transduced with the p185-IRES-Cre oncofusion virus to generate p185+ B-ALL cells in which Mcl-1-deletion is rescued by loss of both BAX and BAK (hereafter referred to as DKO p185+ B-ALL cells). The gene discussed is EIF3A; the disease is acute lymphoblastic leukemia.