The panel of re-programmed p185+ B-ALL cells (expressing exogenous BCL-2, BCL-XL, BCL-W, BFL-1, or MCL-1) or DKO leukemic cells lacking the intrinsic apoptotic pathway were cultured with titrated doses of BH3-mimetic agents and then analyzed for induction of apoptosis 24 hours later by staining with Annexin-V and propidium iodide (PI). This evidence concerns the gene BCL2A1 and acute lymphoblastic leukemia.