Treatment of the panel of p185+ B-ALL cells with navitoclax induced the cell death only of leukemic cells re-programmed to be dependent on BCL-2 (IC50 = 94 nM), BCL-XL (IC50 = 146 nM), and BCL-W (IC50 = 162 nM) (Figure 3A). The gene discussed is EIF3A; the disease is acute lymphoblastic leukemia.