Despite the reports of efficacy of A-1210477 as a single agent in other cell types, it did not induce any selective cell death in any of our re-programmed p185+ B-ALL cells with death of BCL-2, BFL-1, and MCL-1 expressing cells only occurring at high concentrations (IC50 > 2 μM) (Figure 3F). Here, EIF3A is linked to acute lymphoblastic leukemia.