When UM-36 was applied to the panel of re-programmed leukemia cells it induced apoptosis in p185+ B-ALL cells re-programmed to express human MCL-1 (IC50 = 2.5 μM) and, to a lesser extent, in cells expressing BFL-1 (IC50 = 3.4 μM) (Figure 3D). The gene discussed is EIF3A; the disease is leukemia.