EBAG9 and neoplasm: In pT2–pT4 tumors, we observed an increase in Tregs frequency before surgery (Treg-pre) in tumors with cytoplasmic expression of RCAS1 in the border parts (BPs) of the tumor, characterized by a high mitotic index, the presence of small nests of tumor cells, inflammatory infiltration, and/or type of stromal modeling pattern (Figure 6A).