High Ly6E mRNA expression in glioma was significantly correlated with poor five-year overall survival (low Ly6E, n=14; high Ly6E, n=14; HR=2.34, p=0.0026, n= number of patient, HR=hazard ratio), shown by PROGgeneV2 (Table S2, Figure 2A). The gene discussed is LY6E; the disease is central nervous system cancer.