Ly6E mRNA expression was significantly higher in superficial bladder cancer (n=28) than infiltrating bladder cancer (n=81) and high expression of Ly6E was correlated with higher grade (infiltrating grade 3, n=75 vs infiltrating grade 2, n=6) in Sanchez-Carbayo [17] study. The gene discussed is LY6E; the disease is urinary bladder cancer.