High Ly6D mRNA expression in colon cancer was significantly correlated with poor outcome in relapse free survival (low Ly6D, n=25; high Ly6D, n=26; HR=1.19, p=0.0469) and overall survival (low Ly6D, n=25; high Ly6D, n=26; HR=1.63, p=0.0199) shown by PROGgeneV2 (Table S1) and overall survival in 5-year overall survival (low Ly6D, n=15; high Ly6D, n=20, p=3.9E-02) in Smith study [72] (Table 2). This evidence concerns the gene LY6D and colonic neoplasm.