High Ly6E mRNA expression in breast cancer was significantly correlated with decreased one-year metastasis free survival (metastasis, n=49 vs metastasis free, n=148), decreased three year metastasis free survival (metastasis, n=168 vs metastasis free, n=426) in Bos [71], Schmidt [117], Kao [52] and Hatzis [63] studies. Here, LY6E is linked to breast carcinoma.