EIF2AK2 and viral infectious disease: A variety of viruses have been shown to induce the formation of SG in infected cells [18], which is strictly regulated in a steady state; however, once cells are exposed to viral infections, double-stranded RNA (dsRNA)-inducible protein kinase R (PKR) is activated by viral dsRNA (vdsRNA), an intermediate product generated within the viral replicative life cycle [19].