To arrive at the sites of distant metastasis, PCa cells must degrade and cross five separate tissue borders containing the large heparan sulfate proteoglycan (HSPG) perlecan/HSPG2 [4, 5], a multimodular five domain ECM proteoglycan with N-terminal heparan sulfate (HS) and/or chondroitin sulfate (CS) glycosaminoglycan (GAG) chains [6]. The gene discussed is HSPG2; the disease is posterior cortical atrophy.