This study sought to reveal the relationship of levels of perlecan, perlecan fragments, the perlecan degrading metalloproteinase MMP-7, and a multifunctional tissue factor and activator of metalloproteinase, β2M, in PCa tissue and serum collected at the time of prostatectomy from a large 288 patient cohort. This evidence concerns the gene B2M and posterior cortical atrophy.