Furthermore, EBP50 interacts with pleckstrin-homology domain leucine-rich repeat protein phosphatases (PHLPP) and scaffolds it with PTEN to form a tumor suppressor complex, which inhibits the oncogenic phosphatidylinositol-3-OH kinase (PI3K)-Akt signaling pathway [13]. The gene discussed is NHERF1; the disease is neoplasm.