Functional analysis of mutated GAS5 lncRNA sequence has revealed that while apoptosis induction in lymphoid cells is only partially dependent on the GAS5 HREM sequence, more complete dependence is observed in breast and prostate cancer cells [22], implicating riborepression as the major mechanism by which GAS5 lncRNA induces the death of these cells. This evidence concerns the gene GAS5 and prostate cancer.