To test whether the HREM oligonucleotide exerts similar activity to GAS5 lncRNA in this respect, breast cancer cells were nucleofected with either the HREM or control (Scram and SL) oligonucleotides and then, after 24 h, cells were irradiated with UV-C light at dosages to induce apoptosis in ca. 50% cells. The gene discussed is GAS5; the disease is breast cancer.