Literature data indicate reduced FSH and LH serum concentrations determined in HF male rats (27), which is considerably compatible with our immunohistomorphometric findings in the milieu of obesity, as well as with the subsequent leptin resistance related hypogonadotropic hypogonadism found in overweight and obese males (28). The gene discussed is BRD2; the disease is obesity due to melanocortin 4 receptor deficiency.