The lack of effect of ghrelin on LH cells in the HF group of animals could be explained by relatively low doses of centrally administrated ghrelin and/or by pattern of delivery (injections vs. infusions), as numerous studies have shown that the dosage regimen and experimental approach change the degree of inhibitory influence of ghrelin on LH cells (32,34,35). The gene discussed is GHRL; the disease is hydrops fetalis.