In both groups receiving ICV injectionof ghrelin (GNF and GHF), body weights weresignificantly increased (P<0.05) by 8.4 and 5.7%,respectively, in comparison with NF and HF controls.Absolute pituitary weight in HF control ratswas significantly increased (P<0.05) by 35.9% incomparison with NF controls, but not significantlychanged in ghrelin treated animals (GNF andGHF) compared to the NF and HF controls. This evidence concerns the gene GHRL and hydrops fetalis.