STAT3 and colorectal cancer: Other mechanisms proposed for STAT3mediated regulation of invasion include control ofWASF3 protein activation (51) or through inductionor suppression of effector miRs expression.MiR-34a is directly repressed by STAT3 and it hasbeen demonstrated that in colorectal cancer an activeIL-6R/STAT3/miR-34a loop is necessary forEMT, invasion and metastasis (52).