Bourguignon et al. (43) uncovereda functional link between NANOG and STAT3.These researchers reported that hyaluronan (HA)binding to CD44 induced NANOG activation and its interaction with STAT3 which resulted inSTAT3 specific transcriptional activation, MDR1gene expression, and tumor cell growth in humanbreast and ovarian tumor cells. This evidence concerns the gene STAT3 and neoplasm.