STAT3 and breast carcinoma: Thus, our recent experiments in accordance withprevious evidences have shown the potential rolesof the STAT3 signaling pathway in developmentof chemoresistance or regulation of EMT in GCSCs.Based on the investigation on glioblastomaand breast cancers, STAT3 overactivation has beenrecognized to be essential for proliferation, sphereformation, EMT and tumorigenesis of CSCs (16,17, 53, 54).