Three members of the HSP90 gene family (HSP90AA1, HSP90AB1, and HSP90B1) analyzed were all down-regulated following OCT4B1 suppression in all three tumor cell lines except for HSP90B1 in AGS cells that showed less than 2-fold up-regulation (Table 1,Fig .4). This evidence concerns the gene HSP90B1 and neoplasm.