Over expression of miR-144 is associated with severity of anemia and decreased hemoglobin/hematocrit cell count, and also leads to the lack of antioxidant proteins such as glutamate-cysteine ligase, catalytic/modifier subunit (GCLC/M) and superoxide dismutase 1 (SOD1) (44). This evidence concerns the gene SOD1 and anemia (phenotype).