Several members which were previously downregulated in Ph+ ALL cases (Additional file 1: Figure S1a) were now upregulated upon TKI treatment including Jdd1 (Dnajc9), Mdg1 (Dnajb9), Tpr2 (Dnajc7), Erdj1 (Dnajc1), Mcj (Dnajc15) and Auxilin-2 (Gak), while others, previously upregulated in Ph+ ALL cases such as Auxilin-1 (Dnajc6), Nedd7 (Dnaja1), Rdj2 (Dnaja2), Tid1 (Dnaja3) and Dnajc16 were downregulated upon TKI treatment (Additional file 1: Figure S2a). The gene discussed is DNAJA2; the disease is acute lymphoblastic leukemia.