Depending on the site where they develop, ALTCL were categorized into three types: systemic lymphomas, which are usually present in lymph nodes, namely the anaplastic lymphoma kinase (ALK) positive and ALK negative lymphoma, based on the presence of the ALK protein on the surface of the malignant cell and a third non-systemic type, appearing only on the skin, which is also called a primary cutaneous anaplastic large cell lymphoma. The gene discussed is ALK; the disease is anaplastic large cell lymphoma.