Since it is known that ROR1/2 signaling, especially after stimulation with Wnt5a, requires Dvl for signal transduction [42, 43], we aimed to analyze which of the Dvl proteins (Dvl1, Dvl2 or Dvl3) might be a good marker for active ROR signaling in breast cancer. The gene discussed is WNT5A; the disease is breast carcinoma.