Considering that among the Dvl proteins, Dvl3 has already been shown to be highly expressed in cancer patient samples [44–46] and to affect the biological behavior of lung cancer cells mainly through p38 and JNK pathway [47], we decided to include Dvl3, together with c-Jun, as markers for β-catenin independent WNT signaling. The gene discussed is MAPK8; the disease is lung cancer.