Thus, the expression of estrogen and progesterone receptor in the breast cancer primaries is associated with better survival analyzed from the time point of first diagnosis (ER HR: 0.09 95 % CI [0.01–0.56], p =  0.0015 and PGR HR: 0.21 95 % CI [0.05–0.92], p = 0.0245) (Fig. 3a and Table 1). This evidence concerns the gene ESR1 and breast carcinoma.