Hyperglycemia induces the production of pro-inflammatory cytokines and growth factors by activating key signaling pathways associated with MAPK (mitogen-activated protein kinases), NF-κB (nuclear factor-κB), and STAT3 (signal transducers and activators of transcription) [27, 31, 43, 44] depending on ROS and oxidative stress. Here, STAT3 is linked to Hyperglycemia.