C3 and age-related macular degeneration: On the other hand, several AMD susceptible genes, including cholesterylester transfer protein (CETP), superkiller viralicidic activity 2-like (SKIV2L), complement component 3 (C3), elastin (ELN), and apolipoprotein E (APOE) showed different association profiles between AMD and PCV11, 14, 15, 16, 17.