VEGFA and age-related macular degeneration: Hypoxic RPE cells can produce angiogenic substances, such as vascular endothelial growth factor (VEGF), to stimulate the growth of new vessels from choriocapillaris complex, resulting in CNV34.In the original UK GWAS26, rs12153855 and rs9391734 were significantly associated with AMD, minor alleles of these two polymorphisms were risk factors.