In the present study, we have genotyped these 6 SNPs in the 6p21.3 region (including rs541862, rs429608, rs12153855, rs9391734, rs2071277 and rs3132946) and 2 major AMD associated SNPs (rs800292 in CFH and rs11200638 in HTRA1) using SNaPshot method, and tested their associations with both neovascular AMD and PCV in a Han Chinese population composed of 490 neovascular AMD patients, 419 PCV patients and 1316 controls. This evidence concerns the gene HTRA1 and age-related macular degeneration.