Interestingly, the DAVID functional enrichment of the KEGG pathway demonstrated that proteins that preferentially bind 2N Tau are more enriched in Parkinson disease (adjusted p = 0.0073), Alzheimer disease (adjusted p = 0.0121), and Huntington disease (adjusted p = 0.0082), whereas proteins that preferentially bind 0N and 1N Tau showed no significant enrichment. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.