SOCS3 and systemic-onset juvenile idiopathic arthritis: It was reassuring to note that in the DEGs from the PBMC of tocilizumab-treated sJIA patients, there was decreased expression of SOCS3, a suppressor of cytokine signalling, consistent with the fact that tocilizumab decreases intracellular IL-6 signalling and therefore reduction in the expression of SOCS3. We have previously reported that specific innate immune genes are upregulated in PBMC of sJIA patients during active disease [2].