These clinical features are reminiscent of the heritable autoinflammatory diseases; consequently, sJIA is frequently referred to as an autoinflammatory disease because of these clinical manifestations, lack of autoantibodies, and association with variants in inflammatory and anti-inflammatory cytokine genes, including IL-1, IL-6, and IL-10 [3–8]. The gene discussed is IL6; the disease is systemic-onset juvenile idiopathic arthritis.