In addition, we observed decreased tumor growth in mice injected with 4T1 cells expressing shRNAs against Wnt11 (Fig. 6B,C), and reduced proliferation in WNT11 knockout cells in vitro (Fig. 4E), suggesting that impaired tumor progression in Wnt11 shRNA allograft is secondary to reduced proliferation. The gene discussed is WNT11; the disease is neoplasm.