Although elevated WNT11 was not observed in tumors derived from glioblastoma spheroids from two patients implanted in rat23 (data not shown), we tested effects of bevacizumab in an orthotopic malignant glioma mouse model, and found that anti-VEGF treatment increased HIF-1α and HIF-2α, and also induced expression of WNT11 mRNA and protein (Fig. 7). This evidence concerns the gene EPAS1 and malignant glioma.