VEGFA and lung cancer: Evidences for the soluble factor-mediated antitumor capacity of hMSC-CM have been reported such as the reduction of SK-MES-1 and A549 lung cancer cell proliferation by a downregulation of vascular endothelial growth factor (VEGF) expression and by an increased apoptosis ratio compared with the non-hMSC-CM-treated cells [7].