The tumorigenesis of malignant gliomas has been associated with a number of alterations in related genes causing functional loss of tumor suppressors including PTEN, p53, NF1, RB1 or p16 proteins, and hyperfunction of oncogenic proteins such as EGFR, cyclin D1/3, E3 ubiquitin-protein ligase Mdm2, Mdm4, Met, Bcl-2, cyclin dependent kinase 4/6, PDGFRA and PI3K [2]. The gene discussed is EGFR; the disease is malignant glioma.