They showed that some lipid metabolism-related genes (i.e., Mod1, Cyp4a10, Hmgcs2, Acot1, Acot2, Pdk4, Acaa1b, Cpt1, Fabp1, and Acadl) were significantly up-regulated in the intestine of both A/J (obesity-resistant) and C57BL/6J (obesity-prone) mice fed with high fat diet. Here, HMGCS2 is linked to obesity due to melanocortin 4 receptor deficiency.