In the present study, we systematically investigated the effects of MSCs and MSC-CM treatment in mouse models of TAA-induced FHF and CCl4-induced chronic liver fibrosis in terms of enhancing liver regeneration, reducing hepatocellular apoptosis, down-regulating macrophage infiltration, altering the CD4+ T system into an anti-inflammatory state and promoting HSC apoptosis and inhibition of proliferation (Fig. 8). This evidence concerns the gene CD4 and TNF receptor 1-associated periodic fever syndrome.