They found that repetitive hypoxia caused by OSA stimulates the production of inflammatory mediators including CRP, IL-1, IL-6, IL-8, TNF-α, etc. These mediators can activate inflammatory pathways and further contribute to endothelial dysfunction, metabolic dysregulation, and sympathetic excitation7, 8. This evidence concerns the gene CXCL8 and obstructive sleep apnea syndrome.