The CM from CD34+ cells treated with metformin displayed augmented levels of VEGFA either under euglycemia (1.6-fold, p = 0.008), euglycemia combined with hypoxia (1.4-fold, p = 0.037), and hyperglycemia combined with hypoxia (1.2-fold, p = 0.037) compared with the metformin-untreatedcondition (Fig. 1). This evidence concerns the gene CD34 and Hyperglycemia.