Furthermore, metformin downregulated the angiogenic inhibitors TIMP1 [30] (−1.68-fold, p = 3.90E−04), and CXCL10 [31] (−2.01-fold, p = 1.28E−02), whilst had no effect on expression of pro-angiogenic factors under hyperglycemia–hypoxia versus no metformin. This evidence concerns the gene TIMP1 and Hyperglycemia.